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Altered cholesterol ester cycle in skin fibroblasts from patients with Alzheimer's disease.
Intracellular cholesterol metabolism was reported to modulate amyloid-beta (Abeta) generation in Alzheimer's disease (AD). Results presented herein demonstrated that, like brain cells, cultured skinExpand
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Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients
BackgroundCholesterol homeostasis dysfunction has been reported to have role in the pathogenesis of Alzheimer disease (AD). Therefore, changes in cholesterol metabolism in blood components may helpExpand
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Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of disease
BackgroundAlzheimer's disease is the most common progressive neurodegenerative disease. In recent years, numerous progresses in the discovery of novel Alzheimer's disease molecular biomarkers inExpand
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Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease
There is great interest in developing reliable biomarkers to support antemortem diagnosis of late-onset Alzheimer's disease (AD). Early prediction and diagnosis of AD might be improved by theExpand
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Glucose-6-phosphate-dehydrogenase deficiency as a risk factor for pterygium.
PURPOSE Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway (PPP), providing reducing power (NADPH) and pentose phosphates. The purposeExpand
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Polychlorobiphenyls and polycyclic aromatic hydrocarbons in the sea-surface micro-layer and the water column at Gerlache Inlet, Antarctica.
The enrichment of PCBs (polychlorobiphenyls) and PAHs (polycyclic aromatic hydrocarbons) in the sea-surface micro-layer and depth profile of these pollutants in the water column were investigated atExpand
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Modulation of cholesterol homeostasis by antiproliferative drugs in human pterygium fibroblasts.
PURPOSE The authors have previously shown that the growth of cultured fibroblasts obtained from primary pterygia was associated with an increase in cholesterol esterification, suggesting thatExpand
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Antiprion Activity of Cholesterol Esterification Modulators: a Comparative Study Using Ex Vivo Sheep Fibroblasts and Lymphocytes and Mouse Neuroblastoma Cell Lines
ABSTRACT Our studies on the role of cholesterol homeostasis in the pathogenesis of scrapie revealed abnormal accumulation of cholesterol esters in ex vivo peripheral blood mononuclear cells (PBMCs)Expand
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Fibroblasts isolated from human pterygia exhibit altered lipid metabolism characteristics.
To determine whether the fibrovascular proliferation observed in pterygium, may be, at least in part, mediated by an increased activity of cholesterol metabolism. The correlation between lipidExpand
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Cholesterol esterification during differentiation of mouse erythroleukemia (Friend) cells
Cholesterol is an essential constituent of all mammalian cell membranes and its availability is therefore a prerequisite for cellular growth and other functions. Several lines of evidence are nowExpand
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