Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Foreign gene expression in yeast: a review.

• Michael A. Romanos, C. A. Scorer, Jeffrey J. Clare
• Yeast
• 1992

0749-503X/92/060423-66 $38.00

Rapid Selection Using G418 of High Copy Number Transformants of Pichia pastoris for High–level Foreign Gene Expression

• C. A. Scorer, Jeffrey J. Clare, W. Richard McCombie, Michael A. Romanos, Koti T. Sreekrishna
• Bio/Technology
• 1994

Pichia pastoris is a methylotrophic yeast increasingly important in the production of therapeutic proteins. Expression vectors are based on the methanol–inducibte AOX1 promoter and are integrated… (More)

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function

• Peter R. Maycox, F. J. Kelly, +16 authors Jackie de Belleroche
• Molecular Psychiatry
• 2009

Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The pathophysiology of the illness is not understood, but is thought to have a strong genetic component with some… (More)

Transcription and pathway analysis of the superior temporal cortex and anterior prefrontal cortex in schizophrenia.

• Michael R. Barnes, Julie Huxley-Jones, +18 authors Jacqueline S de Belleroche
• Journal of neuroscience research
• 2011

The molecular basis of schizophrenia is poorly understood; however, different brain regions are believed to play distinct roles in disease symptomology. We have studied gene expression in the… (More)

The intracellular production and secretion of HIV-1 envelope protein in the methylotrophic yeast Pichia pastoris.

• C. A. Scorer, Richard G. Buckholz, Jeffrey J. Clare, Michael A. Romanos
• Gene
• 1993

The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein, gp120 (ENV), is required in large quantities for immunological studies and as a potential vaccine component. We have expressed… (More)

Preclinical and clinical challenges in the development of disease-modifying therapies for Alzheimer's disease.

• C. A. Scorer
• Drug discovery today
• 2001

The neurodegenerative disease first described almost 100 years ago by Alois Alzheimer is predicted to be one of the major health problems of the 21st century. Alzheimer's disease (AD) is a… (More)

The generation of multicopy recombinant strains.

• Maria Teresa Vilela Romanos, C. A. Scorer, Koti T. Sreekrishna, J. Clare
• Methods in molecular biology
• 1998

Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation.

• Giu-Jie Feng, Elaine Kellett, C. A. Scorer, Jonathan I. Wilde, Julia H. M. White, Graeme Milligan
• The Journal of biological chemistry
• 2003

Analysis of interactions between the C-terminal tail of the MOP-1 and MOP-1A variants of the human mu-opioid receptor with proteins derived from a human brain cDNA library resulted in identification… (More)

Studies towards the identification of a new generation of atypical antipsychotic agents.

• Vincenzo Garzya, Ian T Forbes, +20 authors Emiliangelo A Ratti
• Bioorganic & medicinal chemistry letters
• 2007

A rational structure-activity relationship study around compound (1) is reported. The lead optimisation programme led to the identification of sulfonamide (25), a molecule combining dopamine D2/D3… (More)

Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha).

• P A Finney, Louise E Donnelly, +8 authors Mark A. Giembycz
• British journal of pharmacology
• 2001

1. The aim of the present study was to examine the effects of chronic infusion of the long-acting agonist salmeterol on pulmonary beta(2)-adrenoceptor function in Sprague-Dawley rats in vivo and to… (More)

• ‹
• 1
• 2
• ›