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Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens.
The increase in the emergence of antibiotic-resistant microorganisms and difficult to treat infections caused by these pathogens stimulate research aiming the identification of novel antimicrobials.Expand
Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum.
This communication reports the separation of 80 fractions from the venom of the Ischnuridae scorpion Opisthacanthus cayaporum by high-performance liquid chromatography (HPLC). From these, 93 distinctExpand
Toxicity and toxin identification in Colomesus asellus, an Amazonian (Brazil) freshwater puffer fish.
Toxicity and toxin identification in Colomesus asellus, an Amazonian (Brazil) freshwater puffer fish. By using four different techniques--mouse bioassay, ELISA, HPLC and mass spectrometry-weExpand
Further report of the occurrence of tetrodotoxin and new analogues in the Anuran family Brachycephalidae.
Tetrodotoxin (TTX) is one of the most potent toxin already isolated, which occurs in a wide range of marine as well as terrestrial animals such as in newts and anurans. In this work, the occurrenceExpand
Venomic and pharmacological activity of Acanthoscurria paulensis (Theraphosidae) spider venom.
In the present study we conducted proteomic and pharmacological characterizations of the venom extracted from the Brazilian tarantula Acanthoscurria paulensis, and evaluated the cardiotoxicity of itsExpand
The occurrence of 11-oxotetrodotoxin, a rare tetrodotoxin analogue, in the brachycephalidae frog Brachycephalus ephippium.
11-oxoTTX is an analogue 4-5 times more toxic than TTX itself, been rare even in marine animals. Two ions at m/z 320 and 336 corresponding to TTX and 11-oxoTTX (M+H(+)), respectively, were detectedExpand
The largest lungless tetrapod: report on a second specimen of Atretochoana eiselti (Amphibia: Gymnophiona: Typhlonectidae) from Brazil
The discovery is reported of a second specimen of the radically divergent lungless aquatic caecilian Atretochoana eiselti (Taylor), previously known only from the holotype. Aspects of the morphologyExpand
Composition of indolealkylamines of Bufo rubescens cutaneous secretions compared to six other Brazilian bufonids with phylogenetic implications.
The composition of indolealkylamines of Bufo rubescens cutaneous secretions was compared to those from six other Brazilian bufonids. Skin, parotoid and tibial gland secretions were obtained forExpand
Ocellatins: New Antimicrobial Peptides from the Skin Secretion of the South American Frog Leptodactylus ocellatus (Anura: Leptodactylidae)
The emergence, in recent years, of microbial resistance to commonly used antibiotics has aroused a search for new naturally occurring bactericidal and fungicidal agents that may have clinicalExpand
Occurrence of tetrodotoxin and its analogues in the Brazilian frog Brachycephalus ephippium (Anura: Brachycephalidae).
Brachycephalus ephippium is a diurnal frog, that shows aposematic colouration and inhabits Atlantic forest leaf litter in south-eastern Brazil. The presence of tetrodotoxin (TTX) in the skin, liverExpand