C. A. Gray

Publications67
h-index18
Citations1,572
Highly Influential Citations56
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Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
TLDR
A yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the modes of action of compounds is presented, and a new class of sterol-binding compounds is discovered.
The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins.
Isolation and bioassay screening of fungal endophytes from North Atlantic marine macroalgae
TLDR
Sixty-four distinct endophytes were isolated from four species of brown, three species of red, and two species of green marine algae collected from the Shetland Islands, UK, with the highest diversity of isolable fungi being obtained from the green algae.
Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?
TLDR
Endophytic fungi from Bay of Fundy macroalgae represent a significant source of antibiotic natural products and warrant further detailed investigation, according to their morphology.
Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase.
Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits…
Polyketides from an Endophytic Aspergillus fumigatus Isolate Inhibit the Growth of Mycobacterium tuberculosis and MRSA
The crude extract of Aspergillus fumigatus isolate AF3-093A, an endophyte of the brown algaFucus vesiculosus, showed significant antimicrobial activity in initial bioactivity screens. Bioassay-guided…
Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis.
Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula.
TLDR
Homodolastatin 16, a higher homologue of the potential anticancer agent dolastAT 16, exhibited moderate activity against oesophageal and cervical cancer cell lines.
Optimisation of the microplate resazurin assay for screening and bioassay-guided fractionation of phytochemical extracts against Mycobacterium tuberculosis.
TLDR
The study has identified an optimal procedure for the microplate resazurin assay when used with M. tuberculosis H37Ra that gives rapid, reliable and consistent results.
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