• Publications
  • Influence
Anterograde transport of brain-derived neurotrophic factor and its role in the brain
The role of neurotrophins as target-derived proteins that promote neuron survival following their retrograde transport from the terminals to the cell bodies of neurons has been firmly established inExpand
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Electroconvulsive Seizures Regulate Gene Expression of Distinct Neurotrophic Signaling Pathways
Electroconvulsive therapy (ECT) remains the treatment of choice for drug-resistant patients with depressive disorders, yet the mechanism for its efficacy remains unknown. Gene transcription changesExpand
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Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation.
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays critical roles in the survival, growth, and maintenance of brain and peripheral neurons. We report the presence ofExpand
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Neurotrophins and depression.
  • C. A. Altar
  • Medicine
  • Trends in pharmacological sciences
  • 1 February 1999
Exogenous delivery of the neurotrophic factors, brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), promotes the function, sprouting and regrowth of 5-HT-containing neurones in theExpand
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Neurotrophic factors: from molecule to man
Recent advances in the understanding of the physiological role of nerve growth factor (NGF) have raised the question of whether neurotrophic factors might have clinical potential in the treatment ofExpand
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A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996-2013.
OBJECTIVE This literature review assessed the burden of treatment-resistant depression in the United States by compiling published data about the clinical, societal, and economic outcomes associatedExpand
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BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration
We have previously demonstrated alterations in serotonin metabolism within descending pathways following infusion of brain-derived neurotrophic factor (BDNF) into the midbrain, near theExpand
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BDNF Promotes the Regenerative Sprouting, But Not Survival, of Injured Serotonergic Axons in the Adult Rat Brain
Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons in the adult brain and can prevent the severe loss of cortical 5-HT axons caused by theExpand
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Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain
BACKGROUND The antidepressant-like effects of brain-derived neurotrophic factor (BDNF) infusions in brain, and the upregulation of BDNF mRNA and its receptor in rats exposed to electroconvulsiveExpand
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Neurotrophin trafficking by anterograde transport
The ever-unfolding biology of NGF is consistent with a target-derived retrograde mode of action in peripheral and central neurons. However, another member of the neurotrophin family, brain-derivedExpand
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