C el Moatassim

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1. The apparent Ki values of (-)-noradrenaline (NA), (+)- and (-)-adrenaline (Ad), phenylephrine and the mono-fluorinated NAs (in position 2, 5 or 6) for alpha 1-adrenoceptors of intact BC3H1 cells labelled with [3H]-prazosin were greatly dependent on the incubation temperature. 2. The EC50 values of these compounds for stimulation of the inositol phosphate(More)
Increased rates of monovalent cation fluxes are implicated in the activation of lymphocytes by mitogens. Our report shows that amiloride and dimethylamiloride, two inhibitors of the Na+/H+ antiport, dose dependently prevent the proliferation of mitogen-activated human peripheral blood lymphocytes. The action of these drugs follows several mechanisms, since(More)
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