C. de Souza

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BACKGROUND Tenofovir disoproxil fumarate (TDF) has been linked to renal impairment, but the extent to which this impairment is reversible is unclear. We aimed to investigate the reversibility of renal decline during TDF therapy. METHODS Cox proportional hazards models assessed factors associated with discontinuing TDF in those with an exposure duration of(More)
OBJECTIVES To determine protease mutations that develop at viral failure for protease inhibitor (PI)-naive patients on a regimen containing the PI atazanavir. METHODS Resistance tests on patients failing atazanavir, conducted as part of routine clinical care in a multicentre observational study, were randomly matched by subtype to resistance tests from(More)
The paper presents the Oi experience on the implementation, through simulations, of a model for reducing non quality process costs of three categories: non-conformance issues, service failures and loss of income due to lack of quality. The model is based on concepts of improved quality, and enables the identification of the cost of non-quality factors. The(More)
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