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The pharmacokinetic parameters of cefotetan were determined in six healthy adults after intramuscular (im) and intravenous (iv) administration of a single dose. After an iv bolus injection of 1 g cefotetan the mean peak serum level was 179.6 mg/l (S.E.M. +/- 14.2 mg/l) at 2 min. The apparent volume of distribution was 10.29 l (S.E.M. +/- 0.66 l). After im(More)
Cefotiam, a new broad-spectrum cephalosporin was used for the treatment of 30 cases of urinary-tract infections (UTI). Patients, 20 females, 10 males were between 23 and 76 years old. UTI were 17 cystitis, 9 pyelonephritis and 4 prostatitis. Bacteria isolated from urine were : 24 E. Coli, 3 Proteus mirabilis, 1 Providencia, 3 Klebsiella, 3 Enterobacter, 2(More)
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