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Cell-penetrating peptides (CPPs) are cationic peptides that are able to induce cellular uptake and delivery of large and hydrophilic molecules, that otherwise do not cross the plasma membrane of eukaryotic cells. Despite their potential use for gene transfer and drug delivery, the mode of action of CPPs is still mysterious. Nonetheless, the interaction with(More)
Genetic algorithm in the bioinformatic can be categorised into many different groups by the implementations they were instructed. Each approach has its own pros and cons. When making a choice between GA approaches to data mining, it is important that the scientist knows the advantages and disadvantages of each approach. In this project a suitable GA(More)
The interaction of patulin with human serum albumin (HSA) was studied in vitro under normal physiological conditions. The study was performed using fluorescence, ultraviolet-visible spectroscopy (UV-Vis), circular dichroism (CD), atomic force microscopy (AFM), and molecular modeling techniques. The quenching mechanism was investigated using the association(More)
Double-peak emission of hot electrons has been observed in the interaction of a 60-fs, 125-mJ, 800-nm, p-polarized laser pulse with Al targets. One peak in the specular direction is due to the reflected laser light, which excites a plasma wave to accelerate electrons. The other peak, which is more consistent with theories of Phys. Plasmas 6, 2855 (1999)](More)
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