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The behavioural and neurochemical effects of m-tyrosine and a monoamine oxidase inhibitor in the rat are described. Systemic injections of m-tyrosine (50-150 mg/kg) 30 min after the administration of pargyline (75 mg/kg) produced intense behavioural stimulation which was not evident after injection of either compound alone. The behavioural syndrome induced(More)
The concentration of dopamine in striatal slices obtained from rats treated with an MAO inhibitor was increased significantly by a 50-minute incubation in oxygenated Krebs buffer at 37 degrees C. Administration of alpha-methyl-p-tyrosine did not antagonize this small increase in dopamine. The extent of the incubation-induced increase was much greater in(More)
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