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A glass with a composition (in mole %) of: SiO2 (70), CaO (26), and P2O5 (4) was obtained using a sol-gel method. The in vitro bioactivity of the glass was assessed by determining the changes in surface morphology and composition after soaking in simulated body fluid (SBF) for periods of up to 14 days at 37 degrees C. X-ray diffraction, scanning electron(More)
Composite materials have been prepared from bioactive glass powders in the SiO(2)-CaO-P(2)O(5) system, a biodegradable polymer [poly(L-lactic acid) (PLA)], a biostable polymer [polymethylmethacrylate (PMMA)], and an antibiotic [gentamicin]. The purpose of such composites is to obtain implantable materials that are able to lead to bone growth and also can,(More)
The ibuprofen (IB) release from samples composed by SiO2-CaO-P2O5 bioactive glass, poly-L-lactic acid (PLA), and polymethylmethacrylate (PMMA) has been studied. Data showed a fast anti-inflammatory drug release during the first 8h when these polyphasic materials are soaked in simulated body fluid (SBF). The analysis of the samples before and after different(More)
OBJECTIVE The study compared the effects of feeding rats a choline deficient (CD) diet or injecting low doses of methotrexate (MTX) on hepatic folate concentration and distribution, homocysteine (Hcy) concentration and DNA methylation. METHODS Thirty rats were divided into three groups and were fed either a choline sufficient (CS) or deficient diet (CD),(More)
Gentamicin sulfate has been incorporated in composites prepared from a SiO2-CaO-P2O5 bioactive glass and polymethylmethacrylate. Data showed that these materials could be used as drug delivery system, keeping the bioactive behavior of the glass. The composites supply high doses of the antibiotic during the first hours when they are soaked in simulated body(More)
The preparation, characterization, and in vitro release of Ibuprofen from Al2O3, poly(L-lactic acid) (PLLA), and polymethylmethacrylate (PMMA) composites are described. The release process of the anti-inflammatory drug after the immersion of composites in a buffered solution is analyzed. The rate of Ibuprofen release is related to the crystalline or(More)
Biomaterial pieces, with suitable osteogenic properties for use in the treatment of bone defects and the capability to avoid bone infections, have been synthesized. These materials are composed exclusively of gentamicin sulfate and bioactive SiO(2)-CaO-P(2)O(5) sol-gel glass (previously synthesized). Implant processing was achieved by uniaxial and isostatic(More)
Two composite systems composed of alpha-Al2O3/poly(methyl methacrylate) (PMMA)/poly(vinyl pyrrolidone) (PVP)/ibuprofen or alpha-Al2O3/PMMA/co-vinyl pyrrolidone-methyl methacrylate/ibuprofen were prepared by free radical polymerization. These systems were characterized by spectroscopic techniques and thermogravimetric and differential thermal analyses. The(More)
Hydroxyapatite/solgel glass biphasic material has been obtained in order to improve the bioactivity of the hydroxyapatite (OHAp). A mixture of stoichiometric OHAp and the precursor gel of a solgel glass, with nominal composition in mol% CaO-26, SiO2-70, P205-4, has been prepared. The amounts of components used have been selected to obtain a final(More)
Biomaterial pieces with osteogenic properties, suitable for use in the treatment of bone defects, were synthesized. The materials, which avoid bone infections, are exclusively composed of gentamicin sulfate and bioactive SiO2-CaO-P2O5 sol-gel glass (synthesized previously), and were manufactured by means of uniaxial and isostatic pressure of the mixed(More)