While trying to learn how to use current collaboration systems, users face many challenges, including difficulty trying out new features and experimenting without their actions affecting other users. This paper proposes an innovative approach to solve these problems by simulating the collaboration system. In this simulated environment, a user can: confirm… (More)
This paper proposes that social navigation can solve many of the challenges facing user experience in collaborative systems. Three key values and three phases of design for social navigation support are identified. The values of social navigation support in collaboration are: discovery of new features; predicting the consequence of certain actions and… (More)
BACKGROUND Infective endocarditis is a life threatening complication of intravenous drug abuse, which continues to be a major burden with inadequately characterised long-term outcomes. We reviewed our institutional experience of surgical treatment of infective endocarditis in active intravenous drug abusers with the aim of identifying the determinants… (More)
BACKGROUND vascular endothelial cell activation and dysfunction are observed in patients with severe heart failure and may contribute to systemic manifestations of this syndrome. It remains unknown whether inflammatory activation of these cells occurs in these patients because of increased circulating proinflammatory mediators. AIM to determine whether… (More)
BACKGROUND The purpose of this prospective study was to evaluate the effects and functional outcome of central extracorporeal life support (ECLS) with left ventricular decompression for the treatment of refractory cardiogenic shock and lung failure. METHODS Between August 2010 and August 2013, 12 consecutive patients (2 female) with a mean age of 31.6 ±… (More)
Left ventricular assist devices are becoming an established treatment for end-stage heart failure. In spite of their proven benefit, pump thrombosis remains a significant complication. Here we describe the challenging management of a patient with recurrent pump thrombosis.
Background—We have previously shown that a specific combination of drug therapy and left ventricular assist device unloading results in significant myocardial recovery, sufficient to allow pump removal, in two thirds of patients with dilated cardiomyopathy receiving a Heartmate I pulsatile device. However, this protocol has not been used with nonpulsatile… (More)
physiology, especially those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a publishes original papers that deal with diverse area of research in applied