C. Rick Lyons

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  • Dana E. Nuti, Reva B. Crump, Farida Dwi Handayani, Narisara Chantratita, Sharon J. Peacock, Richard Bowen +8 others
  • 2011
UNLABELLED Detection of microbial antigens in clinical samples can lead to rapid diagnosis of an infection and administration of appropriate therapeutics. A major barrier in diagnostics development is determining which of the potentially hundreds or thousands of antigens produced by a microbe are actually present in patient samples in detectable amounts(More)
  • Sean M. Rollins, Amanda Peppercorn, John S. Young, Melissa Drysdale, Andrea Baresch, Margaret V. Bikowski +8 others
  • 2008
In vivo induced antigen technology (IVIAT) is an immuno-screening technique that identifies bacterial antigens expressed during infection and not during standard in vitro culturing conditions. We applied IVIAT to Bacillus anthracis and identified PagA, seven members of a N-acetylmuramoyl-L-alanine amidase autolysin family, three P60 family lipoproteins, two(More)
Francisella tularensis causes the disease tularemia. Human pulmonary exposure to the most virulent form, F. tularensis subsp. tularensis (Ftt), leads to high morbidity and mortality, resulting in this bacterium being classified as a potential biothreat agent. However, a closely-related species, F. novicida, is avirulent in healthy humans. No tularemia(More)
Ideally biosignatures can be detected at the early infection phase and used both for developing diagnostic patterns and for prognostic triage. Such biosignatures are important for vaccine validation and to provide risk stratification to a population such as for the identification of individuals who are exposed to biological or chemical agents and who are at(More)
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