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Au nanoparticle (nAu) based electrochemical platform for the amperometric sensing of isoniazid at sub-nanomolar level is developed. The sol-gel derived 3-dimensional silicate network pre-assembled on a conducting substrate is chemically decorated with nAu of 70-100 nm by seed-mediated growth approach. The Au nanoseeds are first chemisorbed onto the thiol(More)
A novel 3-D nanoarchitectured platform based on Pt nanoparticles (nPts) is developed for the sensing of sub-nanomolar levels of hydrogen peroxide and for the fabrication of amperometric biosensor for uric acid, cholesterol and glucose. The nPts have been immobilized on the thiol functional group containing sol-gel silicate 3-D network derived from(More)
A new approach for the one-pot synthesis of reduced graphene oxide-dendritic Pd nanoparticle (rGO-nPd) hybrid material and the development of biosensing scaffold for the amperometric sensing of H2O2 and total cholesterol in human serum are described. In situ reduction of both graphene oxide (GO) and PdCl4(2-) in acidic solution was achieved with Zn to(More)
Development of a highly sensitive nanostructured electrochemical biosensor based on the integrated assembly of dehydrogenase enzymes and gold (Au) nanoparticle is described. The Au nanoparticles (AuNPs) have been self-assembled on a thiol-terminated, sol-gel-derived, 3-D, silicate network and enlarged by hydroxylamine seeding. The AuNPs on the silicate(More)
The electrochemical oxidation of NADH and its model compound, N-benzyl-1,4-dihydronicotinamide (DHN), has been studied at gold electrode modified with self-assembled monolayer of terminally substituted thiols/disulfide, i.e., cystamine (CYST), mercaptopropionic acid (MPA) and mercaptoethanol (ME). A substantial decrease in the overpotential (approximately(More)
Gold electrodes modified with cationic self-assembled monolayers (SAMs) of 2,2'-dithiobisethaneamine (CYST) and 6,6'-dithiobishexaneamine (DTH) were used for the simultaneous determination of dopamine (DA) and ascorbate (AA). The cationic SAM modified electrodes have several advantages over the bare electrode for the oxidation of AA. A very large(More)
Simultaneous electrochemical detection of As(III), Hg(II), and Cu(II) using a highly sensitive platform based on gold nanoelectrode ensembles (GNEEs) is described. GNEEs were grown by colloidal chemical approach on thiol-functionalized solgel derived three-dimensional silicate network preassembled on a polycrystalline gold (Au) electrode. GNEEs on the(More)
Electrocatalytic sensing of NADH using a hybrid thin film derived from multi-wall carbon nanotubes (CNTs), Nafion (Nf) polymer and electrogenerated redox mediator is described. The redox mediator was electrochemically generated by the oxidation of serotonin on the hybrid thin film modified glassy carbon electrode (GC/Nf-CNT). Controlled potential(More)
This article describes the synthesis of branched flower-like gold (Au) nanocrystals and their electrocatalytic activity toward the oxidation of methanol and the reduction of oxygen. Gold nanoflowers (GNFs) were obtained by a one-pot synthesis using N-2-hydroxyethylpiperazine-N-2-ethanesulphonic acid (HEPES) as a reducing/stabilizing agent. The GNFs have(More)
Redox-active molecular architectures are electrochemically derived on the electrode surface by Michael addition reaction of o-quinone with surface adsorbed nucleophiles. Electrogenerated o-quinone undergoes facile Michael addition reaction with nucleophile mercaptotriazole (MTz) and mercaptoimidazole (MIm) preassembled on Au electrode. The Michael addition(More)