C. Radouco-Thomas

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Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities were determined in adult flies from several Drosophila species endowed with widely different tolerance to ethanol (ETOH). Plotting ALDH against ADH activities resulted in a high correlation coefficient (r = 0.966). This finding was confirmed in developmental studies. From early larval(More)
The presence of psychopathological syndromes in alcoholic in-patients was assessed using the NIMH-Diagnosis. The most stricking finding of this study was the high percentage of additional psychopathological syndromes associated to alcoholism. Based on this finding, a tentative classification of alcoholism is proposed. The urgent need for a comprehensive(More)
The extensive literature on dementia of Alzheimer type (DAT) testifies to the enormous progress achieved in the clinical and biochemical delineation of this disease. Newly developed laboratory and imaging techniques are also being applied to the diagnosis of DAT. Nevertheless, unequivoval diagnosis still relies primarily on morphological data from biopsy or(More)
Aldehyde dehydrogenase (ALDH) activity is demonstrated in two mutant strains ofD. melanogaster lacking active aldehyde oxidase (ALDOX). The levels of ALDH activity are compared with those found for the wild strain ofD. melanogaster and its sibling speciesD. simulans. These data provide a rational explanation for the capacity of ALDOX-null flies to detoxify(More)