• Citations Per Year
Learn More
Peptide hydrolases (EC 3.4.-.-) were solubilized from purified brush borders of rat intestinal mucosa by papain digestion. Three peptide hydrolases, I, II, and III, with different substrate specificities were isolated by means of DEAE-cellulose chromatography and preparative acrylamide gel electrophoresis. On repeat preparative acrylamide gel(More)
  • C R Shoaf
  • Environmental health perspectives
  • 1991
The need for assessing noncancer risks for agents to which humans are routinely exposed indoors arises from the large amount of time spent indoors (i.e., employed persons spend about 60% of their time at home indoors, 30% at work indoors, and 5% in transit). Sources of air pollutants include heating and cooling systems, combustion appliances, personal use(More)
The observed rate of phenylalanine absorption into rat intestinal rings with 0.5 or 5.0 mM phenylalanine is greater than that for absorption of phenylalanine from 0.25 or 2.5 mM Phe-Phe, respectively. With the amino acid phenylalanine, V for absorption is the same whether Na+ is present (149 mM) or absent, but the concentration at which the half-maximal(More)
The saturable nature of the clearance of soluble nickel compounds from the lung was studied by repeated exposures of rats to respirable submicron-size nickel aerosols. Using Michaelis-Menten type kinetics for removal of nickel lung burdens and a constant rate of deposition, the lung nickel burdens were simulated by computer. The computer simulation was used(More)
Adult male Fischer rats were given a single po dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equal to 2 times the LD50 to increase the serum and liver lipid concentrations and to induce mortality. In addition, animals were given 4-aminopyrazolo-[3,4-d]-pyrimidine (4APP), an agent that decreases serum lipids, or adenine (Ad), an agent that prevents the(More)
  • 1