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Study of the tyrosine hydroxylase enzyme from substantia nigra and striatum during the aging period of the rat has discovered a significant decrease (55%) of TH activity in substantia nigra between 12 and 24 mo of age. The amount of TH in substantia nigra also decreased (30%) during aging. This loss in TH activity of substantia nigra appears to be produced(More)
1-methyl-4-phenylpyridinium (MPP+) is the bioactivated product of 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridine (MPTP). The neurotoxic action of MPP+ injected intracerebroventricularly (ICV) in the rat has been studied, using dopaminergic systems in the substantia nigra, striatum, olfactory bulb, median eminence and hypophysis. The following results were(More)
We have studied the turnover of dopamine, noradrenaline, and serotonin and their metabolites in hippocampus of adult female rats that were fed control or selenium-deficient diets during 15 days. Under these circumstances, there was an increase of dopamine turnover (4-fold) in rats fed with selenium-deficient diet with respect to controls and also an(More)
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