C. P. Unsworth

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SUMMARY Independent component analysis (ICA) has recently been applied to epileptic seizure in the EEG. In this paper, the authors show how the fundamental axioms required for ICA to be valid are broken. Four common cases of childhood seizure are presented and assessed for stationarity and an eigenvalue analysis is applied. In all cases, for the stationary(More)
It is estimated that the adult human brain contains 100 billion neurons with 5-10 times as many astrocytes. Although it has been generally considered that the astrocyte is a simple supportive cell to the neuron, recent research has revealed new functionality of the astrocyte in the form of information transfer to neurons of the brain. In our previous work(More)
In this communication, we describe a new method which has enabled the first patterning of human neurons (derived from the human teratocarcinoma cell line (hNT)) on parylene-C/silicon dioxide substrates. We reveal the details of the nanofabrication processes, cell differentiation and culturing protocols necessary to successfully pattern hNT neurons which are(More)
We report here the patterning of primary rat neurons and astrocytes from the postnatal hippocampus on ultra-thin parylene-C deposited on a silicon dioxide substrate, following observations of neuronal, astrocytic and nuclear coverage on strips of different lengths, widths and thicknesses. Neuronal and glial growth was characterized 'on', 'adjacent to' and(More)
In this letter, we use the firing rates from an array of olfactory sensory neurons (OSNs) of the fruit fly, Drosophila melanogaster, to train an artificial neural network (ANN) to distinguish different chemical classes of volatile odorants. Bootstrapping is implemented for the optimized networks, providing an accurate estimate of a network's predicted(More)
In this letter, we demonstrate that the generalization properties of a neural network (NN) can be extended to encompass objects that obscure or segment the original image in its foreground or background. We achieve this by piloting an extension of the noise injection training technique, which we term excessive noise injection (ENI), on a simple feedforward(More)
The xCELLigence technology is a real-time cellular biosensor, which measures the net adhesion of cells to high-density gold electrode arrays printed on custom-designed E-plates. The strength of cellular adhesion is influenced by a myriad of factors that include cell type, cell viability, growth, migration, spreading and proliferation. We therefore(More)