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Down syndrome (DS) is the most common aneuploid chromosomal disorder at birth. Phenotypic characteristics include mental retardation, general hypotonia, pharyngeal hypoplasia, frequently constricted maxillary arch with macroglossia and upper air way obstruction. Generally they have marked language difficulties and a characteristic voice. This prospective(More)
A male Afro-descendant patient, 57 years old, complaining of polyarticular involvement and weight loss for 18 months, with a load of 13.5 pack years of smoking. On physical examination there was pain on palpation of the right knee and right leg, with signs of inflammation on the knee. We also observed digital clubbing in all fingers. Antinuclear antibodies(More)
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