C. Naga Raju

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A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides 8(a-e)/carbothioamides 8(f-j) were accomplished for biological interest by the simple addition of active functionalized arylisocyanates 7(a-e)/arylisothiocyanates 7(f-j) with(More)
Owing to the promising antiviral activity of amino acid ester-substituted phosphorylated nucleosides in the present study, a series of phosphorylated derivatives of emtricitabine and didanosine substituted with bioactive amino acid esters at P-atom were synthesized. Initially, molecular docking studies were screened to predict their molecular interactions(More)
A series of new N-substituted sulfonamides, 9-(substituted phenylsulfonyl)-4-(oxiran-2-ylmethoxy)-9H-carbazole 6(a-d) and carbamates, substituted phenyl/aliphatic-4-(oxiran-2-ylmethoxy)-9H-carbazole-9-carboxylate8(a-f) were synthesized in high yields through simple straight forward reaction of 4-(oxiran-2-ylmethoxy)-9H-carbazole (3) with various substituted(More)
One pot three-component PEG-SO(3)H catalyzed reaction of 4-(Pyridin-4-yl)benzaldehyde and triethyl phosphite with various primary amines afforded α-aminophosphonates with high yields by the Kabachnik-Field's reaction. These new structurally diversified set of α-aminophosphonates (4a-j) were evaluated for their anti-tumor activity on human chronic myeloid(More)
Synthesis of a series of novel phosphorylated ganciclovir derivatives with bioactive amines/aminoacid esters as substituents was accomplished. These compounds were structurally characterized by IR, NMR (1H, 13C, 31P), mass spectra and CHN analysis. The compounds (5a–m) have been evaluated for its in vitro and in vivo immunomodulatory activities. The amino(More)
The synthesis of a series of novel α-aminosubstituted phosphonates was accomplished by the reaction of various substituted aldehydes with an amine amlodipine (3-ethyl 5-methyl (±)2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridene-3,5-dicarboxylate) followed by diethylphosphite/dibutylphosphite in ethanol using SnCl(2).2H(2)O as a(More)
A series of novel urea/thiourea derivatives of diphenylphosphoramidate have been synthesized in two steps. In the first step, 4-aminoaniline/4, 4’diaminodiphenylsulfone (Dapsone) was reacted with diphenyl chlorophosphate in the presence of triethylamine (TEA) to get intermediates. Intermediates further treated with various substituted aromatic isocyanates/(More)
In order to increase the binding energy with haemaglutinin–neuraminidase (HN) protein of Newcastle disease virus (NDV), to improve the membrane permeability and to increase antiviral activity, modified structures of didanosine (ddI) were designed by phosphorylation and substitution with various bio-active amines. The designed derivatives revealed better(More)
DNA Cryptography is a new cryptographic paradigm from hastily growing bio molecular computation, as its computational power will determine next generation computing. As technology is growing much faster, data protection is getting more important and it is necessary to design the unbreakable encryption technology to protect the information. In this paper, we(More)
A class of novel N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-substituted sulfonamide 3(a-f) and methyl (2'-(1Htetrazol-5-yl)biphenyl-4-yl)-substituted carbamate 5(a-d) derivatives were synthesized from (2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine, an important drug intermediate and using pharmacologically active functionalized sulfonyl chlorides and(More)