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One pot three-component PEG-SO(3)H catalyzed reaction of 4-(Pyridin-4-yl)benzaldehyde and triethyl phosphite with various primary amines afforded α-aminophosphonates with high yields by the Kabachnik-Field's reaction. These new structurally diversified set of α-aminophosphonates (4a-j) were evaluated for their anti-tumor activity on human chronic myeloid(More)
DNA Cryptography is a new cryptographic paradigm from hastily growing bio molecular computation, as its computational power will determine next generation computing. As technology is growing much faster, data protection is getting more important and it is necessary to design the unbreakable encryption technology to protect the information. In this paper, we(More)
Synthesis of a series of novel phosphorylated ganciclovir derivatives with bioactive amines/aminoacid esters as substituents was accomplished. These compounds were structurally characterized by IR, NMR (1H, 13C, 31P), mass spectra and CHN analysis. The compounds (5a–m) have been evaluated for its in vitro and in vivo immunomodulatory activities. The amino(More)
The synthesis of a series of novel α-aminosubstituted phosphonates was accomplished by the reaction of various substituted aldehydes with an amine amlodipine (3-ethyl 5-methyl (±)2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridene-3,5-dicarboxylate) followed by diethylphosphite/dibutylphosphite in ethanol using SnCl(2).2H(2)O as a(More)
A series of novel urea/thiourea derivatives of diphenylphosphoramidate have been synthesized in two steps. In the first step, 4-aminoaniline/4, 4’diaminodiphenylsulfone (Dapsone) was reacted with diphenyl chlorophosphate in the presence of triethylamine (TEA) to get intermediates. Intermediates further treated with various substituted aromatic isocyanates/(More)
In order to increase the binding energy with haemaglutinin–neuraminidase (HN) protein of Newcastle disease virus (NDV), to improve the membrane permeability and to increase antiviral activity, modified structures of didanosine (ddI) were designed by phosphorylation and substitution with various bio-active amines. The designed derivatives revealed better(More)
A class of novel N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-substituted sulfonamide 3(a-f) and methyl (2'-(1Htetrazol-5-yl)biphenyl-4-yl)-substituted carbamate 5(a-d) derivatives were synthesized from (2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine, an important drug intermediate and using pharmacologically active functionalized sulfonyl chlorides and(More)
A new class of biologically active 13-membered phosphorus-macroheterocycles (6a-l) were conveniently synthesized from 1,2-bis(salicylidene amino)-phenylene (1), by treating with phosporusoxychloride (3) and followed by reacting with various aromatic thiols and amines (5f-l) in one path, and in another path 1 was directly treated with various(More)
In the title compound, C(21)H(18)BrN(2)O(5)P, the six-membered oxaza-phosphinine ring is in a twist-boat conformation. One of the phosphoryl O atoms is in an equatorial configuation while the other is axial with respect to the oxaza-phosphinine ring. The mean planes of the benzene ring to which the nitro group is attached and the phenyl ring form a dihedral(More)
Synthesis of 1-substituted-1,3,2-diazaphosphole 1-oxides (3a-l) were accomplished via a two-step process. It involves the preparation of diazaphospholo 1-oxide monochloride intermediate (2) and its subsequent reaction with phenols/amino acid esters in dry THF in the presence of triethylamine at 40-45°C. The structures of newly synthesized compounds were(More)