C. Naga Raju

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Synthesis of a series of novel phosphorylated ganciclovir derivatives with bioactive amines/aminoacid esters as substituents was accomplished. These compounds were structurally characterized by IR, NMR (1H, 13C, 31P), mass spectra and CHN analysis. The compounds (5a–m) have been evaluated for its in vitro and in vivo immunomodulatory activities. The amino(More)
DNA Cryptography is a new cryptographic paradigm from hastily growing bio molecular computation, as its computational power will determine next generation computing. As technology is growing much faster, data protection is getting more important and it is necessary to design the unbreakable encryption technology to protect the information. In this paper, we(More)
In order to increase the binding energy with haemaglutinin–neuraminidase (HN) protein of Newcastle disease virus (NDV), to improve the membrane permeability and to increase antiviral activity, modified structures of didanosine (ddI) were designed by phosphorylation and substitution with various bio-active amines. The designed derivatives revealed better(More)
Synthesis of a series of novel iminophosphorane derivatives of Zidovudine (AZT) was accomplished through Staudinger reaction. In the first step PBr 3 was reacted with various substituted phenolic and amino compounds in the presence of triethylamine (TEA) in dry tetrahydrofuran (THF) under nitrogen atmosphere followed by cyclisation of (±) 2-aminomethyl(More)
The DNA Cryptography is more efficient technique to provide security by converting the plain text into the DNA sequence. The DNA sequence consisting of four alphabets A, C, G and T. Each alphabet is related to a nucleotide. DNA can be used to store, transmit the data and used for computation of the security for the data. The existing DNA technique takes(More)
A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides 8(a-e)/carbothioamides 8(f-j) were accomplished for biological interest by the simple addition of active functionalized arylisocyanates 7(a-e)/arylisothiocyanates 7(f-j) with(More)
In the title compound, C(21)H(18)BrN(2)O(5)P, the six-membered oxaza-phosphinine ring is in a twist-boat conformation. One of the phosphoryl O atoms is in an equatorial configuation while the other is axial with respect to the oxaza-phosphinine ring. The mean planes of the benzene ring to which the nitro group is attached and the phenyl ring form a dihedral(More)
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