C Murakami

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Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells. In vitro and in vivo assays revealed that leptin has angiogenic activity. In vivo, leptin induced neovascularization in(More)
We present a rare case of chronic active Epstein-Barr virus (EBV) infection showing various clinical outcomes. A 26-year-old man was admitted to our hospital due to persistent fever and dyspnea. Serologic response of the patient to EBV indicated chronic active infection. He showed pleuritis, parotitis, chronic hepatic dysfunction, disseminated intravascular(More)
Effects of 5-hydroxytryptamine (5-HT) on neurons of the rat dorsolateral septal nucleus (DLSN) were examined by intracellular and whole-cell patch-clamp recording techniques. An outward current was induced by 5-HT (1-100 microM) in a concentration-dependent manner. The EC(50) for 5-HT was 4.8 microM. Also, 8-OH-DPAT (10-100 microM) produced the outward(More)
The effect of the benzodiazepine receptor antagonist flumazenil was examined on an antiaggressive effect of (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3- benzodioxole HCl (MKC-242), a 5-HT(1A) receptor agonist. MKC-242 (0.1-1.0 mg/kg, p.o.) selectively reduced isolation-induced aggressive behavior in a dose-dependent manner. Flumazenil (10(More)
Afferent and efferent components in the lingual and pharyngeal branches of the glossopharyngeal nerve (Li and Ph) of the Japanese monkey (Macaca fuscata) were examined. After injecting wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) unilaterally into the central cut end of the Li and Ph, or into the stylopharyngeal muscle, labeled neuronal(More)
The purpose of this study was to examine the cognitive structure of the schizophrenic patients. Two, one word sentence, "father" and "mother", with 15 different emotional expressions were given by both male and female announcers as verbal stimuli. Stimuli were judged by 29 normal students and 22 schizophrenic patients on 5 monopolar rating scales. Using(More)
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