C. Metzler

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In this study we present further data on case JB who developed memory impairment following a ruptured aneurysm of the anterior communicating artery which resulted in damage centered on the frontal cortex. The data reveal the JB's memory impairment is characterized by a recall impairment in which intrusion rates are abnormally high and a recognition deficit(More)
The present study examined the role of the left frontal cortex in strategic aspects of semantic processing. Participants were tested in a semantic priming task involving the meaning access of ambiguous and unambiguous words. Patients with left or bilateral frontal lesions failed to develop semantic facilitation of context-appropriate homograph meanings(More)
The present study investigated whether lesions to the prefrontal cortex would lead to impaired inhibitory control in selective attention. Patients with uni- and bilateral frontal lobe damage and age-matched control participants were compared in an identity negative priming task involving letter naming. Whereas all control groups revealed robust negative(More)
Eleven healthy subjects received single oral doses of placebo, 2 mg diazepam, 5 mg diazepam, and 10 mg diazepam in a randomized four-way crossover study. Plasma diazepam levels, the Digit Symbol Substitution Test (DSST), and fraction of total electroencephalographic (EEG) amplitude falling in the sigma plus beta (13 to 31 Hz) frequency range were determined(More)
Synchronous programming languages are well-suited for the implementation and verification of real-time systems. The main benefit for the estimation of real-time constraints is thereby that the macro steps provided by synchronous programs can be directly used for runtime analysis: If synchronous circuits are generated from these descriptions, the macro steps(More)
We present evidence here for two stages in B-memory cell development, the first of which is T independent and the second T dependent. For these studies, we use a new type of T-deficient mouse (allotype suppressed) which specifically lacks T-helper activity (Th) for a subset of memory B cells responsible for approximately 10% of the overall IgG antibody(More)
This paper presents the deterministic and stochastic model for a linear compartment system with constant coefficients, and it develops expressions for the mean residence times (MRT) and the variances of the residence times (VRT) for the stochastic model. The expressions are relatively simple computationally, involving primarily matrix inversion, and they(More)
Synchronous programming languages are well-suited for the implementation and verification of real-time systems. The main bene.t for the estimation of real-time constraints is thereby that the macro steps provided by the semantics of synchronous languages can be directly used as building blocks for runtime analysis. We describe a new approach to determine(More)
The Michaelis-Menten equation has been applied successfully in the study of enzyme kinetics. It usually is used to estimate vmax and km from observations of the initial rate of reaction, v, at various substrate concentrations, Cs. A variation of this expression recently was used in pharmacokinetics, where it was assumed that the elimination rate of drug(More)