C. Mark McIntyre

Learn More
PURPOSE Investigational drug services (IDSs) are often responsible for delivery of investigational product, whether to a study participant pursuant to a prescription or in bulk to another investigational study site. These deliveries must often cross state borders. For situations in which the study is not conducted under an investigational new drug(More)
PURPOSE Ifosfamide plus mesna have been used recently in a high-dose regimen that allows this chemotherapy to be given to outpatients with less toxicity over 14 days using a portable pump. However, there is a need for published stability information. The aim of this study was to investigate the physicochemical stability of ifosfamide with mesna in normal(More)
PURPOSE The gastrointestinal absorption sites of medications administered via postpyloric enteral feeding tubes were examined. SUMMARY Many issues must be considered when administering medications via the postpyloric route, including interactions with enteral feeds, additional toxicities, and the concern of whether the medication will be absorbed. Despite(More)
Time delay estimation is a complicated problem if the delay is time-varying as a result of contact motion. This delay estimation is further complicated if multipath and interfering sources are present. This paper describes an algorithm based on the superposition of short time crosscorrelations of the received signals at two sonobuoys. The advantage of this(More)
There is a paucity of data on infant intravenous prostacyclin use, the gold standard for therapy for severe pulmonary hypertension (PH). This review aimed to evaluate the safety, tolerability, and outcomes of infant prostacyclin use. A retrospective observational study was performed in a large pediatric hospital with a dedicated pediatric PH program.(More)
  • 1