C M Hetherington

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Analysis of HLA class II transgenic mice has progressed in recent years from analysis of single chain HLA class II transgenes with expression of mixed mouse/human heterodimers to double transgenic mice expressing normal human heterodimers. Previous studies have used either HLA transgenic mice in which there is a species-matched interaction with CD4 or mice(More)
The male specific antigen, H-Y, which is encoded or controlled by gene(s) situated in the Y chromosome (1), has its probable physiological function in the development of maleness (2). But it is also a weak transplantation antigen which may cause skin graft rejection and the production of cytotoxic T cells (1, 3). The cytotoxic response to H-Y in mice is(More)
The ability of female mice to rapidly reject syngenic male skin grafts is largely determined by dominant genes in the IB region of the H-2b halotype, whereas the ability to produce anti-H-Y cytotoxic cells is determined by a dominant gene in the IA region the H-2b halotype, or by complementary genes in the IC region of some other haplotypes. Thus, it seems(More)
Cross-reactive T-cell cytotoxicity is seen when cytotoxic responses are generated in mixed lymphocyte cultures either between mouse strans which differ at the major histocompatibility complex, H-2, or between H-2b mutant strains and the strain from which they were derived. This cross-reactivity can be measured with [51Cr] labeled target cells from a number(More)
All adult marmosets tested had ureaplasmas in their throats but not in the lower respiratory tract, and rarely in the genital tract. Ureaplasmas persisted in the throat of a marmoset separated from the colony for 44 days. They could not be recovered from the animals for at least nine weeks after a course of minocycline. Airborne reinfection did not occur(More)
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