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Adult male Fischer 344 rats were exposed either to clean air or to a mixture of clean air and 0.5ppm ozone for up to one year. These populations were sampled after three and six months and when the exposure was completed. The activity of several oxidative enzymes in these rat lungs were compared. Although there was no significant increase in the ability of(More)
Monoamine oxidases A and B (amino: oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4) have been identified in the outer membranes of rat liver mitochondria by their covalent reaction with the inhibitor, [3H]pargyline. On analysis by polyacrylamide gel electrophoresis under denaturing conditions. Monoamine oxidase A was found to migrate(More)
Male rats were exposed to 0.125, 0.25 or 0.5 ppm of ozone or clean air for up to 1 year. During this exposure period there was little evidence for collagen accumulation in the lungs. However, the rate of incorporation of tritiated proline into both lung collagen and total lung protein was accelerated. These data suggest that exposure to ozone under these(More)
Clorgyline, a selective MAO-A inhibitor, increased (5 times) rat pineal melatonin and N-acetyl-serotonin (NAS) content, and decreased 5-HIAA level by 80%. Deprenyl, a selective MAO-B inhibitor, did not change melatonin or other pineal indoles content. The data obtained show that inhibition of MAO-A but not B enzyme is responsible for pineal melatonin(More)
The outer membranes of mitochondria prepared from the liver of rats kept 12 days on a choline-deficient diet were analyzed for changes in phospholipid and protein content. The total amount of phospholipid in the outer membranes was not affected by the deficiency. There was, however, a significant decrease in the amount of phosphatidylcholine and an increase(More)
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