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The present study shows that under glucose-deprived conditions immunostimulated astrocytes rapidly undergo death due to their increased susceptibility to endogenously produced peroxynitrite. Fe(III)tetrakis(N-methyl-4'-pyridyl)porphyrin (FeTMPyP), but not the structurally related compounds ZnTMPyP and H(2)TMPyP, prevented the death in glucose-deprived(More)
SETTING Korea is an intermediate-burden country with high rates of tuberculosis (TB) drug resistance. OBJECTIVE To evaluate the performance of the GenoType® MTBDRplus (MTBDR) assay in diagnosing drug-resistant TB in routine practice in Korea. DESIGN The MTBDR assay was performed on 428 samples, and the results were retrospectively compared with the(More)
Controlled release formations of drugs were prepared with matrix materials of the natural polysaccharides sodium alginate and +/--carrageenan. The drugs used were sodium salicylate (anionic) and lidocaine-HCl (cationic). The release characteristics of the drugs were studied under different pH and compositions of aqueous media. The cationic drug(More)
Pretreatment of interferon-gamma and lipopolysaccharides made C6 glioma cells highly vulnerable to glucose deprivation. Neither 12 h of glucose deprivation nor 2-day treatment with interferon-gamma (100 U/ml) and lipopolysaccharides (1 microg/ml) altered the viability of C6 glioma cells. However, significant death of immunostimulated C6 glioma cells was(More)
SETTING The QuantiFERON-TB Gold (QFT-G) test can be used to distinguish between tuberculosis (TB) and non-tuberculous mycobacterial disease, but a high background TB infection rate may pose a problem. Although the QuantiFERON-TB (QFT) test, the first-generation QFT-G test, employs a non-specific PPD antigen, avium sensitin is also used as a stimulating(More)
SETTING A private university hospital in South Korea. OBJECTIVE To investigate the incidence of tuberculosis (TB) among health care workers (HCWs) employed at a university hospital in South Korea. DESIGN The occurrence of TB cases among HCWs over a 6-year period (2001-2006) was reviewed. The prevalence of TB was compared with that of the general(More)
Studies on the molecular structure underlying Br(a)/Br(b) (HPA-5) platelet alloantigen show that a single base polymorphism at position 1648 on platelet mRNA coding for GP Ia results in a amino acid substitution at position 505 on the mature GP Ia which is associated with the two serologically defined Br types. While this polymorphism has no known effects(More)
SETTING South Korea, 2005-2007. BACKGROUND Non-tuberculous mycobacterial diseases presenting as solitary pulmonary nodules (NTM-SPN) are rare and may be misdiagnosed as tuberculoma. DESIGN Eleven NTM-SPN patients were enrolled retrospectively and compared with two groups each of 33 patients with upper lobe cavitary (UC) and nodular bronchiectatic (NB)(More)
The object of this study is to assess the changes in regional cerebral blood flow (rCBF) following stereotactic limbic leukotomy in patients with medically intractable Obsessive-Compulsive Disorder (OCD). Technetium-99-Hexa Methyl Propylene Amine Oxime (99mTc-HMPAO) Single Photon Emission Computed Tomography (SPECT) data obtained before and after limbic(More)