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The effect of p-chlorophenylalanine (p-CPA) on testosterone (T) hypothalamic metabolism and on plasma levels of T, estradiol (E2) and corticosterone (B) was studied in male rats and rabbits: both were sacrificed 48 hours after the last injection. In both rats and rabbits a significant increase in T leads to E2 transformation (aromatization) was evident(More)
In vitro biosynthesis of gonadal steroids from dehydroepiandrosterone was studied in isolated and in socially reared male and female rats. Acetone-dried powder of gonadal tissue incubated with dehydroepiandrosterone-4-14C yielded androstenedione, androst-5-ene-3beta, 17beta-diol, 11beta-hydroxyandrostenedione and testosterone. In the male, conversion to(More)