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When mammals are constrained to hypogravity, their neuromuscular apparatus undergoes modifications which rend difficult postural maintenance and muscular activity upon the return to normal gravitational conditions. Muscle atrophy and differetial gene expression are particularly evident in slow-twitch antigravity muscles such as the soleus. During(More)
Muscle weights, Ca-ATPase activity and calcium-binding proteins were studied after denervation in rat extensor digitorum longus (EDL) and soleus (Sol) muscles. Muscle weights decreased progressively as a function of denervation time: after 28 days EDL weight diminished by 70% and Sol weight by 47%. Ca-ATPase activity and calsequestrin were quite reduced in(More)
Prolonged hypogravity such as during space flights affects skeletal muscle function by inducing postural changes as well as reduced muscle strength and locomotion capacity. Also in rats, space flight as well as useful models of groundbased hypogravity induce marked atrophy in the slow-twitch soleus (SOL) muscle as opposed to slight or none in the(More)
La production de la chaleur de 64 brebis de 7 types génétiques d'ovins a été mesurée en chambres respiratoires pour déterminer l'influence sur leurs dépenses énergéti-ques, de conditions climatiques bien contrôlées simulant les intempéries rencontrées en alpage. À 15°C, en air calme, la thermogenèse des brebis est en moyenne de 3,55 kcal/kg pO , 75 par h.(More)
Isometric tension of K+ contractures, membrane potential, internal Na+ activity (alpha iNa) and intracellular pH (pHi) have been measured in vitro under conditions which modify sarcolemma-bound calcium and the activity of the Na+-Ca2+ exchange of normal mammalian soleus muscle. In the absence of external Na+ and for a given high external K+, the maximum(More)
1. The effects of tetracaine on the membrane currents and contraction of isolated frog atrial trabeculae under voltage clamp has been investigated. 2. Tetracaine inhibits the slow inward current in a competitive way with a Ki of 0.13 mM, and the phasic component of the contractile response in a non-competitive manner with a Ki of 0.25 mM. 3. The tonic phase(More)
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