C L van Broeckhoven

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BACKGROUND Memory problems are a main feature of mild cognitive impairment (MCI) and may be related to the apolipoprotein E (APOE) epsilon4 allele. We investigated whether the effect of the APOE genotype on memory in subjects with MCI was dependent on age and underlying Alzheimer disease (AD) pathology. METHODS Subjects with MCI (n = 180) were selected(More)
The aim of the study was to investigate the course of objective memory impairment in non-demented subjects who attended a memory clinic and to test predictors of outcome. Non-demented subjects (N=74) were included when they were older than 40 years and had a baseline score on the delayed recall of a word learning test below the tenth percentile. Subjects(More)
A procedure making use of the intracellular arginase activity has been developed for measuring the transport of arginine across the human erythrocyte membrane. (1) The arginine translocation is carrier mediated with simple Michaelis-Menten kinetics, showing one high affinity, low capacity transport system characterized by a half saturation constant KT of(More)
Rat erythrocytes lack arginase as do the erythrocytes of human homozygote patients with hyperargininemia due to arginase deficiency. The rat has physiological liver arginase activity and plasma arginine and ornithine levels between the homozygotes and the heterozygotes with hyperargininemia. In rats, one injection of free arginase induces a transient(More)
Alzheimer disease (AD), the major form of senile dementia, is rapidly becoming a major health problem in developed countries since as populations live longer the number of elderly people continues to grow. Simultaneously, the number of AD cases is increasing since AD is mainly a late-onset disorder and since no effective therapies are available. The primary(More)
Today, results of molecular genetic analyses of familial Alzheimer's disease are not only confusing to those not directly involved in this particular research field but, they are also extremely troublesome to those trying to elucidate the genetic basis of this devastating neurological disorder. Dr. St. George-Hyslop has provided an excellent review of the(More)
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