C L Phillips

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Differential localization of myosin-II isozymes in human cultured cells and blood cells.

Pamela Maupin, C L Phillips, Robert S Adelstein, Thomas D. Pollard
Journal of cell science
1994

We used purified polyclonal antibodies to human cytoplasmic myosin-IIA and myosin-IIB directly labeled with fluorescent dyes to localize these myosin-II isozymes in HeLa cells, melanoma cells and… (More)

Structural changes in human type I collagen fibrils investigated by force spectroscopy.

J. S. Graham, Anthony N Vomund, C L Phillips, Michel Grandbois
Experimental cell research
2004

In the field of biomechanics, collagen fibrils are believed to be robust mechanical structures characterized by a low extensibility. Until very recently, information on the mechanical properties of… (More)

Murine model of the Ehlers-Danlos syndrome. col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages.

Richard J. Wenstrup, Jane B Florer, +5 authors David E. Birk
The Journal of biological chemistry
2006

The most commonly identified mutations causing Ehlers-Danlos syndrome (EDS) classic type result in haploinsufficiency of proalpha1(V) chains of type V collagen, a quantitatively minor collagen that… (More)

Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndrome.

Michael Trenell, Julie A. Ward, +4 authors Campbell H Thompson
Diabetes, obesity & metabolism
2007

AIM To observe the effect of constant positive airway pressure (CPAP) therapy on regional lipid deposition, muscle metabolism and glucose homeostasis in obese patients with obstructive sleep apnoea… (More)

Variable Bone Fragility Associated With an Amish COL1A2 Variant and a Knock-in Mouse Model

Ethan L H Daley, Elizabeth A. Streeten, +9 authors D. J. McBride
Journal of bone and mineral research : the…
2010

Osteogenesis imperfecta (OI) is a heritable form of bone fragility typically associated with a dominant COL1A1 or COL1A2 mutation. Variable phenotype for OI patients with identical collagen mutations… (More)

Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model

Xiaomei Yao, Stephanie M. Carleton, Arin D. Kettle, Jennifer R Melander, C L Phillips, Yong Wang
Annals of Biomedical Engineering
2013

Osteogenesis imperfecta (OI) is a dominant skeletal disorder characterized by bone fragility and deformities. Though the oim mouse model has been the most widely studied of the OI models, it has only… (More)

Hindlimb skeletal muscle function in myostatin-deficient mice.

Bettina A. Gentry, J. Andries Ferreira, C L Phillips, Marybeth Brown
Muscle & nerve
2011

Absence of functional myostatin (MSTN) during fetal development results in adult skeletal muscle hypertrophy and hyperplasia. To more fully characterize MSTN loss in hindlimb muscles, the morphology… (More)

Role of genetic background in determining phenotypic severity throughout postnatal development and at peak bone mass in Col1a2 deficient mice (oim).

Stephanie M. Carleton, D. J. McBride, +7 authors C L Phillips
Bone
2008

Osteogenesis imperfecta (OI) is a genetically and clinically heterogeneous disease characterized by extreme bone fragility. Although fracture numbers tend to decrease post-puberty, OI patients can… (More)

Growth in the basicranial synchondroses of adolescent Macaca mulatta.

Warwick Bruce Giles, C L Phillips, Donald R. Joondeph
The Anatomical record
1981

Tritiated thymidine was administered to five Macaca mulatta monkeys ranging in skeletal age from 39 to 48 months. The animals were then serially sacrificed according to the following postinjection… (More)

Oim mice exhibit altered femur and incisor mineral composition and decreased bone mineral density.

C L Phillips, Deborah A. Bradley, +6 authors Laura S. Hillman
Bone
2000

To investigate the role of the pro alpha 2(I) collagen chains of type I collagen in mineralization we used the oim (osteogenesis imperfecta model) mouse as our model system. The oim/oim mouse… (More)

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