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Receptors for the Fc region of IgG (FcyR)' are expressed in a number of hematopoietic cell types and play important roles in several immunological processes such as phagocytosis of opsonized particulate antigens (1), clearance of immune complexes (2, 3), antibody-dependent cellular cytotoxicity (4, 5), signalling the production of inflammatory mediators(More)
This article presents the idea of deening a kernel for object role modelling techniques, upon which diierent drawing styles can be based. We propose such a kernel (the ORM kernel) and deene, as a case study, an ER and a NIAM drawing style on top of it. One of the prominent advantages of such a kernel is the possibility to build a CASE-tool supporting(More)
Glucocorticoids (Gc) act through the glucocorticoid receptor (GR) to enhance or repress transcription of glucocorticoid-responsive genes depending on the promoter and cellular context. Repression of proopiomelanocortin (POMC) gene expression by Gc was proposed to use different mechanisms. We described the POMC promoter Nur response element (NurRE) as a(More)
The NGFI-B (Nur77) subfamily of orphan nuclear receptors (NRs), which also includes Nurr1 and NOR1, bind the NurRE regulatory element as either homo- or heterodimers formed between subfamily members. These NRs mediate the activation of pituitary proopiomelanocortin (POMC) gene transcription by the hypothalamic hormone corticotropin-releasing hormone (CRH),(More)
PURPOSE To further characterize a previously described phenotypic variant of geographic atrophy (GA) associated with rapid progression and a diffuse-trickling appearance on fundus autofluorescence (FAF). METHODS Thirty-six patients (60 eyes; 72.2% women; mean age, 69.4 ± 10.7 years) with this distinct phenotype were examined by simultaneous confocal(More)
In this article we briefly present the idea of defining a kernel for object role modelling techniques, upon which different drawing styles can be based. We propose such a kernel (the ORM kernel) and define, as a case study, an ER and a NIAM drawing style on top of it. One of the prominent advantages of such a kernel is the possibility to build a CASE-tool(More)
We have cloned and expressed a cDNA encoding a human receptor for IgG (Fc gamma R) from the monocyte cell line U937. The deduced structure is a 35-kD transmembrane protein with homology to the mouse Fc[gamma 2b/gamma 1] receptor amino acid sequence of approximately 60% in the extracellular domain. The signal sequence is homologous to the mouse Fc gamma R(More)
1064 Centrosome abnormalities during a Chlamydia trachomatis infection are caused by dysregulation of the normal duplication pathway K. 1074 Resistance of Neisseria gonorrhoeae to non-oxidative killing by adherent human polymorphonuclear leucocytes 1088 Distinct activities of Bartonella henselae type IV secretion effector proteins modulate capillary-like(More)
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