C. L. E. Siezen

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Epidemiological and animal studies have suggested that a high ratio of n−3 fish fatty acids to arachidonic acid (AA), might protect against colorectal carcinogenesis. Competition of n−3 and n−6 fatty acids, especially AA, for the enzyme cyclooxygenase-2 may be responsible for this effect. To examine the relation between fish intake and colorectal adenomas,(More)
In the absence of a polyposis phenotype, colorectal cancer (CRC) patients referred for genetic testing because of early-onset disease and/or a positive family history, typically undergo testing for molecular signs of Lynch syndrome in their tumors. In the absence of these signs, DNA testing for germline mutations associated with other known tumor syndromes(More)
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