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Oligodeoxynucleotides containing immunostimulatory CpG motifs (CpG ODN) act as potent Th1-like immune enhancers with many antigens in animal models. We have extended these observations to the first clinical evaluation of the safety, tolerability and immunogenicity of CPG 7909 when added to a commercial HBV vaccine. In a randomized, double-blind phase I dose(More)
The endometriums from 50 hysterectomy patient specimens were studied morphologically and biochemically to determine the effects of the IUD. 13 examples of endometrial histology were selected at different stages of the cycle to illustrate typical changes associated with the use of the IUD. 4 of the cases are presented as controls to illustrate differences(More)
BACKGROUND Pegylated interferon (pegIFN) and ribavirin combination therapy remains the first-line treatment for chronic hepatitis C virus (HCV) infection. In contrast to the wealth of studies in treatment-naive patients, the effectiveness of retreatment in patients who have previously failed pegIFN-based therapy is largely unreported. AIM To assess the(More)
The pupillary dilation reflex of the paralyzed cat was studied during habituation to an acoustic stimulus, The effect of a scheduled stimulus omission was assessed by examination of pupillary activity during the omission, in the 4-sec intertrial interval, and on the following trial. It was found that dilation responses during the omission were rare. Effects(More)
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