C Kopanski

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The effects of 20 tricyclic and 12 chemically unrelated 'atypical' antidepressant drugs on the noradrenaline (NA) receptor coupled adenylate cyclase system were investigated in slices of the rat cerebral cortex. While no changes occurred after a single dose, 14 tricyclic compounds down-regulated the receptor system when administered for 9 days. Six(More)
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