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Using Positron Emission Tomography for dynamic tracer mapping requires the knowledge of the arterial plasmatic activity concentration (PTAC). The reference method to obtain it is arterial sampling, not applicable in clinical studies because invasive and dangerous. The Simultaneous Estimation (SIME) method aims to estimate simultaneously the PTAC and the(More)
PURPOSE The imaging of positron emitting isotopes produced during patient irradiation is the only in vivo method used for hadrontherapy dose monitoring in clinics nowadays. However, the accuracy of this method is limited by the loss of signal due to the metabolic decay processes (biological washout). In this work, a generic modeling of washout was(More)
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