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Transcriptional factors (TFs) and many of their target genes are involved in gene regulation at the level of transcription. To decipher gene regulatory networks (GRNs) we require a comprehensive and accurate knowledge of transcriptional regulatory elements. TRED (http://rulai.cshl.edu/TRED) was designed as a resource for gene regulation and function(More)
Several inward rectifier K+ (Kir) channels are inhibited by hypercapnic acidosis and may be involved in CO2 central chemoreception. Among them are Kir1.1, Kir2.3, and Kir4.1. The Kir4.1 is expressed predominantly in the brainstem. Although its CO2 sensitivity is low, coexpression of Kir4.1 with Kir5.1 in Xenopus oocytes greatly enhances the CO2/pH(More)
In this paper, a method is suggested to solve the nonlinear interval number programming problem with uncertain coefficients both in nonlinear objective function and nonlinear constraints. Based on an order relation of interval number, the uncertain objective function is transformed into two deterministic objective functions, in which the robustness of(More)
Abstract ATP-sensitive K+ (KATP) channels are known to be gated by several intracellular molecules, but the gating mechanisms remain unclear. To understand the relationship of channel gating to ligand binding, we studied Kir6.2 channel gating by ATP and protons, which inhibit and activate the channel, respectively. We have previously shown that a threonine(More)
The ATP-sensitive K+ (KATP) channels couple chemical signals to cellular activity, in which the control of channel opening and closure (i.e., channel gating) is crucial. Transmembrane helices play an important role in channel gating. Here we report that the gating of Kir6.2, the core subunit of pancreatic and cardiac KATP channels, can be switched by(More)
Loop diuretic use has been shown to be associated with an increased fracture risk, but the findings have been inconsistent. The present meta-analysis suggests that loop diuretics show a significant positive association with the overall risk of total fractures and, specifically, hip fractures. Despite being widely used, there is limited, prospective(More)
This paper proposes a unique discovery signal as an enabler of peer-to-peer (P2P) communication which overlays a cellular network and shares its resources. Applying P2P communication to cellular network has two key issues: 1. Conventional ad hoc P2P connections may be unstable since stringent resource and interference coordination is usually difficult to(More)
The aim of this study was to evaluate outcomes of total colonic exclusion with antiperistaltic ileorectal anastomosis (TCE-AIA) for elderly patients with slow transit constipation (STC). Elderly patients (defined as age >65) who underwent TCE-AIA for severe idiopathic STC between 2009 and 2012 at our institution were identified. Postoperative outcomes and(More)
ATP-sensitive K+ channels (KATP) couple the intermediary metabolism to cellular excitability and play an important role in the cardio-protective effect of ischemic preconditioning and the activity-dependent autoregulation of cerebral circulation. Although previous studies using PCR and Northern blot suggest that the vascular isoform may consist of Kir6.1(More)