C. Jason Woodard

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This paper investigates the structure and dynamics of the Web 2.0 software ecosystem by analyzing empirical data on web service APIs and mashups. Using network analysis tools to visualize the growth of the ecosystem from December 2005 to 2007, we find that the APIs are organized into three tiers, and that mashups are often formed by combining APIs across(More)
Antibodies generated to a synthetic decapeptide, RMHLRQYELL, representing the carboxyl-terminus of Gs-alpha have been characterized in immunoblots and functional studies. This antibody, designated RM, reacts exclusively with a doublet of proteins of 52 and 45 kDa in immunoblots of bovine brain and wild-type S49 murine lymphoma cell membranes. No such(More)
As information technology becomes integral to the products and services in a growing range of industries, there has been a corresponding surge of interest in understanding how firms can effectively formulate and execute digital business strategies. This fusion of IT within the business environment gives rise to a strategic tension between investing in(More)
Engineers have traditionally been trained to solve design problems without regard to the potentially competing interests of other designers. But just as technology strategists are increasingly drawn into the technical minutiae of product development decisions, engineers are increasingly exposed to the competitive forces that shape their requirements and the(More)
We describe a novel use of evolutionary computation to discover good districting plans for the Philadelphia City Council. We were able to discover 116 distinct, high quality, legally valid plans. These constitute a rich resource on which stakeholders may base deliberation. The exercise raised the issue of how to deal with large numbers of plans, especially(More)
Recent literature on sociotechnical systems has employed the concept of generativity to explain the remarkable capacity for digital artifacts to support decentralized innovation and the emergence of rich business ecosystems. In this paper, we propose agent-based computational modeling as a tool for studying the evolution of generativity, and offer a set of(More)
Iodohydroxybenzylpindolol (I-HYP) is a chemically defined, high affinity, high specific activity beta-adrenergic antagonist that interacts with a single site on the turkey erythrocyte membrane. Study of the interaction of agonists, antagonists, and congeners with this site and concomitant alterations in adenylate cyclase activity have been carried out in(More)
An iodine-labeled beta-adrenergic inhibitor ((125)l-hydroxybenzylpindolol) binds specifically to a site on turkey erythrocyte membranes. A series of beta-adrenergic agonists and inhibitors compete for this binding site, with apparent affinities paralleling biological effectiveness as activators or inhibitors of catecholaminestimulated adenylate cyclase. The(More)
The radioiodinated beta-blocker iodohydroxybenzylpindolol ([125I]HYP) has been used to identify directly and characterize beta-adrenergic receptors in isolated bovine parathyroid cells. [125I]HYP was bound rapidly and reversibly to isolated bovine parathyroid cell membranes. Scatchard analysis revealed a single class of binding sites with high affinity (4 X(More)