C. James Taylor

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INTRODUCTION Cartilage thickness from MR images has been identified as a possible biomarker in knee osteoarthritis (OA) research. The ability to acquire MR data at multiple centers by using different vendors' scanners would facilitate patient recruitment and shorten the duration of OA trials. Several vendors manufacture 3T MR scanners, including Siemens,(More)
Multi-objective performance optimisation for model predictive control by goal attainment Vasileios Exadaktylos a & C. James Taylor b a Department of Biosystems, Division M3-BIORES: Measure, Model and Manage Bioresponses, Catholic University of Leuven, Kasteelpark Arenberg 30, 3001 Heverlee, Belgium b Department of Engineering, Lancaster University,(More)
In this paper, we develop a discrete time, state variable feedback control regime to analyze the closed-loop properties associated with stabilizing the global mean surface temperature anomaly at 2oC within a sequential decision making framework made up of 20 year review periods beginning in 2020. The design of the feedback control uses an optimal control(More)
Rhodri H. Daviesa, Carole J. Twiningb, Tim F. Cootesb and Chris J. Taylor b a Howard Florey Institute, Univeristy of MelbournebDivision of Imaging Science, University of Manchester Abstract. Statistical shape models are widely used as a basis for segmenting and interpreting images. A major drawback of this approach is the need to identify corresponding(More)
Oxygen-enhanced MR imaging has been demonstrated in a number of recent studies as a potential method to visualize regional ventilation in the lung. A quantitative pixel-by-pixel analysis is hampered by motion and volume change due to breathing. In this study, image registration via active shape modeling is shown to produce significant improvements in the(More)
When using tracer kinetic modeling to analyze dynamic contrast-enhanced MRI (DCE-MRI) it is necessary to identify an appropriate arterial input function (AIF). The measured AIF is often poorly sampled in both clinical and preclinical MR systems due to the initial rapid increase in contrast agent concentration and the subsequent large-scale signal change(More)
We are in the process of developing an automated image analysis system, which uses deformable models of shape, learned from image examples, to interpret video images of rodents. Active shape models provide a compact description of the shape of the animal in a way that enables the postures the differentiate various behaviors to be distinguished. They also(More)
The objective was to measure the effect of 100% oxygen inhalation on T1 relaxation times in skeletal muscle. Healthy volunteers were scanned using three different MRI protocols while breathing medical air and 100% oxygen. Measurements of T1 were made from regions of interest (ROIs) within various skeletal muscle groups. Dynamic data of subjects breathing a(More)