C. J. Hage

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Following an efficient circuit analysis with ideal operational amplifier (op amp) models, approximate results can be rendered realistic in terms of related sensitivity/tolerance computations. Sensitivities of circuit responses to manufacturer specified op amp tolerances complete the analysis by providing nominal and worst-case in-specification output(More)
Cross-linking combined with mass spectrometry (MS) has evolved as an alternative strategy in structural biology for characterizing three-dimensional structures of protein assemblies and for mapping protein-protein interactions. Here, we describe an integrated workflow for an automated identification of cross-linked products that is based on the use of a(More)
We have synthesized a homobifunctional amine-reactive cross-linking reagent, containing a TEMPO (2,2,6,6-tetramethylpiperidine-1-oxy) and a benzyl group (Bz), termed TEMPO-Bz-linker, to derive three-dimensional structural information of proteins. The aim for designing this novel cross-linker was to facilitate the mass spectrometric analysis of cross-linked(More)
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