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The innate immune system is of vital importance for protection against infectious pathogens. Inflammasome mediated caspase-1 activation and subsequent release of pro-inflammatory cytokines like IL-1beta and IL-18 is an important arm of the innate immune system. Salmonella enterica subspecies 1 serovar Typhimurium (S. Typhimurium, SL1344) is an(More)
Tumor progression is controlled by signals from cellular and extra-cellular microenvironment including stromal cells and the extracellular matrix. Consequently, three-dimensional in vitro tumor models are essential to study the interaction of tumor cells with their microenvironment appropriately in a biologically relevant manner. We have previously used(More)
Caspase-1 is an important converging point for danger signals initiating inflammation and defense. Recent work suggests that RhoGTPase activation and/or cyto-skeletal disturbance may represent a novel pathway eliciting caspase-1 responses that are subverted by several enteropathogenic bacteria. The enteropathogen Salmonella Typhimurium employs the type III(More)
— Memetic algorithms (MAs) combine the global exploration abilities of evolutionary algorithms with a local search to further improve the solutions. While a neighborhood can be easily defined for discrete individual representations, local search within real-valued domains requires an appropriate choice of the local search method. If the subject of(More)
There is a continuous trend to modularization since information, communication, data processing and automotive industries ask for integration of active and passive devices and further miniaturization. This paper shows how EPCOS, one of the leading component manufacturers is serving the needs of the industries by making use of their advanced LTCC (low(More)
Modeling of products (objects) form a critical task in design and manufacturing. CAD–CAM techniques based on solid/geometric modeling have been developed for this purpose. Primarily, these methods capture the shape of the object. However, recent developments in diverse fields demand modeling schemes, which extend beyond the shape to include other relevant(More)
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