C. Henninger

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F. Wartlick1
B. Kaina1
C. Hinterleitner1
1F. Wartlick
1B. Kaina
1C. Hinterleitner
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We investigated the relevance of signaling mechanisms regulated by the Ras-homologous GTPase Rac1 for survival of acute myeloid leukemia (AML) cells harbouring the MLL-AF9 oncogene due to t(9;11)(p21;q23) translocation. Monocytic MLL-AF9 expressing cells (MM6, THP-1) were hypersensitive to both small-molecule inhibitors targeting Rac1 (EHT 1864, NSC 23766)(More)
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