C.-H. Olme

Learn More
The CBA/H mouse model of radiation-induced acute myeloid leukaemia (rAML) has been studied for decades to bring to light the molecular mechanisms associated with multistage carcinogenesis. A specific interstitial deletion of chromosome 2 found in a high proportion of rAML is recognised as the initiating event. The deletion leads to the loss of Sfpi, a gene(More)
Acute myeloid leukaemia (AML) is one of the most common malignancies seen to occur in human populations exposed to ionising radiation. 1 Mouse models have been widely used for quantitative and mechanistic studies of radiation leukaemogen-esis; further, there is a similarity in the histopathological changes found in human AML and mouse AML. The majority of(More)
Exposure to ionising radiation can lead to an increased risk of cancer, particularly leukaemia. In radiation-induced acute myeloid leukaemia (rAML), a partial hemizygous deletion of mouse chromosome 2 is a common feature in several susceptible strains. The deletion is an early event detectable 24h after exposure in bone marrow cells using cytogenetic(More)
  • 1