C. H. Martin

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Biocatalysis has become a powerful tool for the synthesis of high-value compounds, particularly so in the case of highly functionalized and/or stereoactive products. Nature has supplied thousands of enzymes and assembled them into numerous metabolic pathways. Although these native pathways can be use to produce natural bioproducts, there are many valuable(More)
BACKGROUND The ability to synthesize chiral building block molecules with high optical purity is of considerable importance to the fine chemical and pharmaceutical industries. Production of one such compound, 3-hydroxyvalerate (3HV), has previously been studied with respect to the in vivo or in vitro enzymatic depolymerization of biologically-derived(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract 24 Enzymes are powerful biocatalysts capable of performing specific chemical 25 transformations under mild conditions. Yet as catalysts they remain subject to the laws 26 of thermodynamics, namely that they cannot catalyze chemical(More)
TRAMP is a software package for generating transposon maps that are used for DNA sequencing. The package provides a variety of automated tools that can always be overridden by the user. The central part of the package is its selection algorithm that finds the most robust map with the smallest number of inserts. TRAMP has been in daily use by the sequencing(More)
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