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The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients.
Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans. CADASIL arteriopathy is characterized by major alterations ofExpand
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Glycohistochemical characterization of vascular muscle cell destruction in CADASIL subjects by lectins, neoglycoconjugates and galectin‐specific antibodies
CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a type of small‐artery stroke and vascular dementia‐inducing pathology of the brain. In orderExpand
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