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The Epstein-Barr virus-encoded nuclear antigens EBNA2 and EBNA3C both interact with the cellular transcription factor RBP-Jkappa and modulate the expression of several shared target genes, suggesting a tight cooperation in latently infected cells. In a survey for additional cellular factors that bind to EBNA2 as well as EBNA3C, we have isolated and(More)
In order to respond to the flood of new active ingredients currently being generated by combinatorial chemistry or molecular biological synthesis, selection procedures able to filter out rapidly and economically those drug candidates with the highest development potential are required. This necessitates the measurement of fundamental biopharmaceutical(More)
In order to reduce costs and shorten time-to-market, the permeability of drug substances can be characterized by in vitro techniques including the use of cell and tissue models. It is required to apply appropriate quality standards similar to those used in animal or clinical studies. The Caco-2 cell model is a well-established and recognized in vitro(More)
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