C. George Sandulescu

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Development of resistance to platinum compounds significantly hinders successful ovarian cancer (OVCA) treatment. In tumor cells, dysregulated pH gradient across cell membranes is a key physiological mechanism of metastasis/chemo-resistance. These pH alterations are mediated by aberrant activation of key multi-subunit proton pumps, Vacuolar-ATPases(More)
A series of mechanical factors, such as postural changes and every day movements, favour mobilization of bronchoalveolar secretions and, hence, offer greater chanses of detecting the tuberculosis bacillus. It is recommended to collect, in out-patient units, two sputum samples, one in the morning and the second several hours later, after beginning the day's(More)
A system consisting of an SPF-500 (Aminco) spectrofluorometer interfaced to a Felix-M18 microcomputer was used for the fluorescence densitometry analysis of aflatoxin fractions separated by silica gel thin-layer chromatography. The efficiency of fluorescence densiotmetry ultramicroanalysis was dependent on the type of aflatoxin (B1, B2, G1, G2 or M1) and on(More)
Six cases are presented (out of a total of 11) with sputum positive pulmonary tuberculosis associated with bronchopulmonary carcinoma. The carcinoma developed during the evolution of 9 cases of active tuberculosis that had received a long discontinous treatment with tuberculostatic drugs. Only two of the 11 patients could be operated because the other 9(More)
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