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OBJECTIVE The etiology of Wegener's granulomatosis (WG) remains unknown. The predominant involvement of the airways and the presence of neutrophilic alveolitis at disease onset have led us to postulate that an inhaled agent may trigger the onset of WG. This study is designed to analyze differences in self-reported environmental exposures between patients(More)
Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic signs and symptoms in 48% of all patients.(More)
BACKGROUND An association between antineutrophil cytoplasmic antibodies (ANCA) and nonimmune complex-mediated glomerulonephritis was first reported over 10 years ago. In Wegener's granulomatosis, the antibody usually binds proteinase 3. Antibodies to a variety of other antigens have been identified in a broad range of diseases. SUMMARY The typical coarse,(More)
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