C. G. Pierrepoint

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Dr P Workman (MRC Clinical Oncology Unit, Cambridge, Chairman); Dr A Balmain (Beatson Institute for Cancer Research, Glasgow); Dr J A Hickman (CRC Experimental Cancer Chemotherapy Research Group, Aston); Dr N J McNally (deputy, Dr A M Rojas, both CRC Gray Laboratory, Northwood); Professor N A Mitchison (University College, London); Dr C G Pierrepoint(More)
Accessory sex glands were removed from rats which were then allowed to mate with females. Ablation of the ventral prostatic lobes appeared to have no affect on the animals' fertility whereas removal of the dorsolateral lobes or of the seminal vesicles induced complete infertility. Excision of the coagulating glands caused infertility in 12/16 males.
Plasma concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), testosterone (T), and 17 beta-estradiol (E2) have been measured in men complaining of infertility in comparison with men of proven fertility. Subgrouping of patients was achieved on the basis of the presence or absence of sperm in the ejaculate and(More)
Patients with histologically proven carcinoma of the prostate (n = 186) were initially assessed and followed up according to the standardized protocol of the British Prostate Study Group, urologists from which contributed patients to this investigation. These patients were given either endocrine therapy or orchidectomy as first line treatment; the ratio of(More)
X-ray microanalysis of zinc in ultrathin sections of dog prostate was performed by electron microscope microanalysis using the potassium pyroantimonate method of preparation. Prostates of both mature and immature dogs were examined and the metal was found to be localised primarily in the nucleolus, nuclear chromatin and secretory granules of epithelial(More)
Neoplastic epithelium derived from a spontaneous canine prostatic adenocarcinoma has been maintained and grown in cell culture and as xenografts in athymic mice. An epithelial cell line (CPA 1) has been isolated from primary cultures and has been partially characterized in vitro. The growth of this cell line was not modified by either androgens or(More)
The epididymis of the dog has been studied with regard to its ability to bind androgens with a high affinity and low capacity. A proteinaceous molecule was demonstrated in the high-speed supernatant fraction of disrupted cells that bound DHT and sedimented in a sucrose density gradient with a sedimentation coefficient of 8S with respect to bovine serum(More)