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Progressive research has been recently made in dissecting the molecular biology of Betanodavirus life cycle, the causative pathogen of viral encephalopathy and retinopathy in economic important marine fish species. Establishment of betanodavirus infectious clone allows the manipulation of virus genome for functional genomic study, which elucidates the(More)
The aquaculture of high market value marine fish, brown-marbled grouper, Epinephelus fuscoguttatus (Forskal) is expanding rapidly. However, this has been limited by the high incidence of disease outbreaks due to intensive culture techniques that included crowded stocking density of fish, the use of agricultural pesticides and antibiotics in fish farming,(More)
The approaches of transcriptomic and proteomic have been widely used to study host-pathogen interactions in fish diseases, and this is comparable to the recently emerging application of metabolomic in elucidating disease-resistant mechanisms in fish that gives new insight into potential therapeutic strategies to improve fish health. Metabolomic is defined(More)
The mechanisms through which brown-marbled grouper accomplishes resistance to infection, particularly against Vibrios, are not yet fully understood. In this study, brown-marbled grouper fingerlings were experimentally infected with Vibrio parahaemolyticus, to identify disease resistance grouper, and the serum proteome profiles were compared between(More)
The brown-marbled grouper, Epinephelus fuscoguttatus (Forskal), is a high-market-value marine fish that is intensively cultured. However, in recent years, it has suffered huge economic losses due to susceptibility to infections (Ku & Lu 2000; Lopez et al. 2002), in particular vibriosis (Liu et al. 2004). A transcriptome-wide examination of gene expression(More)
The gram-negative bacterium, Vibrio alginolyticus, has frequently been identified as the pathogen responsible for the infectious disease called vibriosis. This disease is one of the major challenges facing brown-marbled grouper aquaculture, causing fish farmers globally to suffer substantial economic losses. The objective of this study was to investigate(More)
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