C F Kügler

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Event-related P300 potentials are closely reflecting cognitive functions such as stimulus evaluation time (P300 latency) and task relevance (P300 amplitude). Hence, both their potential clinical application for detecting slight cognitive disturbances and an increasing interest in the aging of cognitive human brain functions resulted in a growing number of(More)
We investigated the influence of eye dominance scaled by 6 tests on the parameters (N80, P100 latency and N80-P100 amplitude) of the white-black-, green-black-, red-black- and blue-black-pattern visual evoked potentials (PVEPs) of 40 healthy subjects (20 males and 20 females) with normal visual acuity. The P100 latency of the white-black PVEPs was, for both(More)
Event-related P300 potentials closely reflect cognitive functions such as stimulus discrimination (N250) and processing time (P300 latencies) as well as attention capabilities (P300 amplitudes). To delineate the age-related dynamics of P300 potentials, we investigated 250 healthy subjects between 18 and 98 years of age in a cross-sectional study. A total of(More)
The dynamics of cognitive brain functions of 104 patients with both chronic non-cirrhotic (NC) and cirrhotic liver disease (C: C1, non-encephalopathic; C2, encephalopathic) were investigated by means of visual P300 potentials elicited in both the paradigms of transient (PI) and selective attention (PII). Conventional PVEPs, psychometric tests and(More)
Visual event-related P300 potentials, conventional visual evoked potentials, and psychometric tests were applied to patients with noncirrhotic chronic liver disease and to clinically nonencephalopathic and encephalopathic cirrhotics to compare their diagnostic efficacy in detecting early portosystemic encephalopathy (PSE). Sixty-four investigations were(More)
Disturbances of sensory functions may additionally impair cognitive functions in elderly persons. To delineate the impact of visual sensory functions on brain signal processing during normal aging from an electrophysiological perspective, we investigated 289 fit community-dwelling subjects (162 men [56%] and 127 women [44%]; age range, 18-98 years) by means(More)
Event-related P300 potentials that closely reflect cognitive brain functions show significant age-related latency prolongations. This aging-P300 interaction can best be approximated by third-order polynomial regressions. To delineate the clinical impact this special kind of regression function may have on detecting early cognitive dysfunction, we applied(More)
Event related P300 potentials as the electrophysiological substrate of cognitive functions, such as the stimulus processing time (P300 latencies) and visual attention capacity (P300 amplitudes) are suitable for the analysis of age-related changes in cognitive human brain functions. P300 investigations carried out in a total of 330 test subjects aged between(More)
For studying the relationship between the PFP300 (Pattern Flash elicited P300) and age we investigated 73 healthy subjects - 34 males, 39 females - between 18 and 60 years of age by presenting randomly two different checkerboards A (16 X 16 caskets visual angle = 50') and B (64 X 64 caskets visual angle = 12.5') to them (A:B = 80:20). The subjects' task was(More)
PF-P300 has been recorded from 13 healthy male subjects (21-35 years) in two different conditions of visual attention (transient versus sustained attention) at 16 electrode locations (10/20-system) against linked mastoids. The PFP300 complexes were measured and mapped. Thus, we obtained the following: (1) N250 did not show any significant differences(More)